Geomatrix technology (Jago Pharma, Muttenz, Switzerland) can control release of one or more drugs from a tablet containing different drugs in different layers. Download/Embed scientific diagram | Geomatrix Technology: two-and three-layer systems. from publication: Development of Controlled Release Three-layered. Geomatrix is the smartest solution to grow your retail sales, available in 67 countries. We integrate best official data and technologies in a single platform.
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The results indicated that when tragacanth was used as a carrier, the release was delayed to a greater extent than when acacia was used. These factors ultimately influence diffusion path length as well as the geomatgix co-efficient.
Table 1 Advantages of multi-layered tablets over conventional tablets Adapted from Namdeo [ 64 ]. The results depicted that the modules did not completely alter the kinetics compared to flat base matrices having the same weight and composition.
A study that was conducted by Fassihi and co-workers investigated zero-order release kinetics from a self-correcting floatable asymmetric configuration drug delivery system.
Studies on applicability of press-coated tablets using hydroxypropylcellulose HPC in the outer shell for timed-release preparations.
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The first beomatrix provided sustained technologyy of the antagonist and the second layer provided a rapid release of the antagonist. In the first type, the two barrier layers were hydrophilic, in the second type, one of the barriers was hydrophobic while the other was hydrophilic and in the third type, the two barrier layers were both hydrophobic [ 65 ].
Preparation of porous and nonporous biodegradable polymeric hollow microspheres. This type of variable release is extremely useful for the delivery of geomxtrix drugs that need both rapid and sustained release. The barrier layer modifies the swelling rate of the active core and reduces the surface area available for diffusion of drug [ 69 — 70 ].
The triple-layered tablet which is exemplified in Figure 3 consists of an active core which is a hydrophilic matrix layer and two polymeric geeomatrix layers on either side that are hydrophobic or semi permeable [ 6667 ]. It has been shown that generally constant drug release can be achieved when both barrier layers are hydrophilic and the core layer is hydrophobic [ 425 ].
The device is also able to deliver up to two drugs simultaneously with varying release profiles [ 36 ]. The controlled release society; The concept of barrier layers have proven to be beneficial in multilayered tablet designs; however converting the barrier layers into additional controlled release drug matrices may hold further potential for future application [ 64 ].
Danckwerts also studied the effectiveness of cup tablets of different depths for use in core-in-cup tablets and the optimal formulation in terms of drug release behavior.
Thus, as amount of drug in the core is depleted the rate of release is increased due to the greater surface area, consequent to swelling. Geomatrix technology is gematrix new drug delivery device in the form of a multi-layer tablet proposed for constant drug release and was developed at University of Pavia, Italy.
Summary technloogy the type of polymers influencing the behavior and release characteristics of multilayered tablets. Coupling of diffusion and relaxation. Longxiao and co-workers also prepared a bilayer osmotic pump tablet using the indented core strategy.
Transport mechanisms technollogy device design. Triple-Layered Tablets Triple-layered tablets are comprised of an inner drug core layer which is sandwiched between two surrounding barrier layers [ 464 ]. These systems may therefore have a significantly beneficial outcome in therapeutic efficacy. These barrier layers may also contain drug and serve as matrices tecunology release drug in various release patterns [ 64 ].
The release rate from these formulations enabled a twice daily administration of the delivery system [ 92 ]. In the past, polymers that were mainly employed for such purposes were the hydropolymers [ 40 ], while currently polymers investigated range from swollen and non-swollen [ 4051 ], porous and non-porous [ 52 — 54 ] to erodible or non-erodible polymers [ 555 ].
For example, multi-kinetics can be achieved and the delivery of two drugs in a single unit at a specific time and at a specific rate can is also possible. More uniform delivery of drug into the systemic circulation can be achieved because bimodal release systems increase the rate of drug release when the ability of the body to absorb the drug decreases.
These include increased patient compliance [ 78 ], selective pharmacological action; reduced side-effect profile and reduced dosing frequency [ 9 ].
Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery
In this case, there is an initial immediate rapid release of drug, which is followed by a sustained constant drug release. Network Engineering and Administration. A bilayered tablet for the delivery of propranolol hydrochloride was developed by Patra and co-workers. The results also indicated that as the size of the hole increased, the rate of drug release also increased.
A study completed by Sundy and co-workers developed a novel compression-coated doughnut-shaped tablet for zero-order sustained release. This can be described as pulsatile release rather than continuous release. Streubel and co-workers developed multilayered matrix tablets that could achieve bimodal drug release rates. The system was evaluated in terms of the release rate of trimetazidine dihydrochloride from the matrix.
Schematic depiction of a multilayered osmotic device Adapted from Fanner et al.
This study poses great potential for the essential eradication of Helicobacter pylori infection that often results in hospitalization of patients who develop serious ulcers [ 98 ]. Rate Control by Means of Geometric Configuration. The barrier layers minimize and therefore delay the interaction of the gastrointestinal environment with the active core, by decreasing the surface area available for drug release or by controlling the rate at which the solvent penetrates the layers [ 40 ].
Controlled-Release Technology, Pharmaceutical Applications. The fact that drug delivery systems with altered geometric technilogy particularly tablets have shown promising results in drug delivery technology and ease of manufacturing is an added advantage to the pharmaceutical industry. Overall, the study showed that the characteristics of the polymers employed had a significant influence on the release profiles of the tablets although the choice of polymers employed in the study was conservative.
The multi dimensional dynamics of Geomatrix -people, processes, technologies The core layer contained theophylline while the outer layers were composed of polymers and excipients in order to delay geomatric interaction of the core layer with water, thereby delaying and controlling the drug release.
A textural analysis study. These systems have been shown to be advantageous over typical tablet systems as depicted in Table 1.
Following the same principle, it is possible to obtain a constant release profile as well as other types of dissolution patterns such as pulsatile or delayed delivery as well as extended drug delivery depending on the characteristics of the polymers employed. Figure 9 shows the typical geometries of core-in-cup tablets. We help clients integrate technologies – including middleware technology, integration applications, and legacy interfaces – to solve complex business problems.
The device was developed to deliver the first therapeutic agent by immediate release and the second in a controlled manner.
Appropriate matching of drug and polymer s provides the desired balance between drug depletion and increased diffusion through the matrix to deliver a steady flux.