Eurand’s Diffucaps® technology enables the development of once-daily controlled-release (CR) capsules or patient-friendly orally disintegrating tablet ( ODT). Download scientific diagram | ORBEXA ® Technology 3) DIFFUCAPS ® Technology: Diffucaps is a multiparticulate bead system comprised of multiple layers of. DIFFUCAPS ® technology 4) DIFFUTAB ® Technology: Diffutab technology enables customized release profiles and region-specific delivery. Diffutab.
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Support Center Support Center. Degradation of HA via the hyaluronidase is very low in a normal state of health. Examples of pH dependent polymers are cellulose acetate phthalate, polyacrylates, and sodium carboxymethylcellulose. This dosage form consists of an insoluble capsule body containing drug and a release controlling plug Soluble is fitted between immediate release compartment and pulsed release compartment Technologyy.
Recent technologies in pulsatile drug delivery systems
Eurand applied this technology to both soluble and insoluble products. Conte U, Maggi L. In addition, 3DP can also provide solutions for resolving difficulties relating to the delivery of poorly water-soluble drugs, peptides and proteins, highly toxic and potent drugs and controlled release of multidrugs in a single dosage forms.
The release-controlling polymer is a combination of ciffucaps soluble and water insoluble polymers.
Some people function best in the morning while others have their peak in the noon or evening. Difgucaps controlled-onset delivery system results in a maximum plasma concentration C max of verapamil in the morning hours.
A new concept of chronopharmaceutics has emerged, wherein research is devoted to the design and evaluate the drug delivery systems that release a therapeutic agent at a rhythm that ideally matches the biological requirement of a given disease therapy2. At this point, degradation products become small enough to be solubilized, and the structure starts to become significantly more porous and hydrated.
Some coatings designed to erode gradually with time, result technoolgy the release of drug contained within the particle. Chronotropic system consists of a core containing drug reservoir coated by a hydrophilic polymer HPMC. Pulsatile drug delivery is defined as the rapid and transient release of certain amount of molecules within a short time period immediately after a predetermined off-released period, i.
This is a site-specific and time-dependent formulation; i. Examples technplogy the pH sensitive polymers include N, N- dimethylaminoethyl methacrylate, chitosan, polyol etc3, 7, 15, The lag time increases with increasing coating thickness and hardness of the core table. Under the influence of the electric field, electroresponsive hydrogels generally deswell, swell or erode.
In the human body numerous kinds of bioactive compounds are exist. The controlled porosity osmotic pump. Glucose-responsive insulin release devices These devices have been developed to respond with changes in glucose concentration in the blood.
J of Advances in Pharmacy, Biology and Chemistry ;1: These products follow the sigmoid release profile characterized by a time period. Pulsatile Delivery by Rupture of Membrane These systems consist of an outer release controlling water tfchnology but permeable coating subject to mechanically induced rupture phenomenon.
The body temperature often deviates from the physiological temperature C in the presence of pathogens or pyrogens.
Internally stimuli induced system 2. Externally Regulated System 3. This proprietary technology has been developed specifically for weak, basic drugs and involves the incorporation of a pharmaceutically acceptable organic acid or a crystallization-inhibiting polymer onto inert cores and coating the drug-layered diffucapss with proprietary functional polymers.
System is composed of a drug-containing core and swells able polymeric coating of HPMC which slow the interaction with aqueous fluids4,8,9,11,13,14,15,16, Multiparticulate Drug Delivery System.
Recent technologies in pulsatile drug delivery systems
Water diffuses across the semi permeable membrane when this cap comes into contact with GI fluids and it results in increased pressure inside that ejects the plug after a predetermined lag time.
Asthma is one such disease where pulsatile drug delivery system can be techbology. Pulsatile drug delivery systems have the potential to bring new developments in the therapy of many diseases. These devices have been developed to respond with changes in glucose concentration in the diffucasp.
These systems consist of reservoir with either rupturable or altered permeability coating and technklogy commonly housed in Capsular body. Eurand Minitabs combine the simplicity of tablet formulation with the sophistication of multiparticulate systems, suitable for high drug loading, and can be used as a sprinkle for pediatric and geriatric patients who have difficulty swallowing tablets. Due to its flexible and highly reproducible manufacturing technologj, 3DP idffucaps some advantages over conventional compressing and other RP technologies in fabricating solid DDS.
There are numerous advantages of the pulsatile drug delivery systems. Formulations using an acid core ensure that an acidic environment surrounds the drug at all times, thereby producing a soluble drug in an in vivo environment where it would otherwise be insoluble. Circadian increase in the blood sugar level after meal has been observed in Diabetes mellitus.
Circadian changes are seen in normal lung function, which reaches a low point in the early morning hours. Orbexa technology is a multiparticulate system that enables high drug loading and is suitable for products that require granulation.